Nutritional Testing

Do you have numerous food allergies, intolerances or sensitivities, that you or your doctor have not been able to resolve or even diagnose? Food intolerance can be a mystery and requires an understanding of how it can develop in the first place.

Food Sensitivities have been found to be the result of a weakened immune system’s learned response to any number of proteins that are permeating or “leaking” into the systemic circulation from the gastrointestinal tract. This is called Intestinal Permeability. Intestinal permeability has been identified as a pre-cursor to immune mediated or delayed food sensitivities. Contributing factors of increased permeability are a low fiber overly processed dietary intake, over exposure to antibiotics, drugs, and or chemicals and pesticides.

Intestinal permeability or “leaky gut” and can be tested as well as identify and quantify the number of antibodies the immune system has created in response to substances it does not recognize and considers “foreign”. Food intolerances are tested by IgG and will identify immune mediated hyperactive responses to proteins in foods. Once these proteins are identified, immune modification can proceed by temporarily removing the food or chemical trigger and re-educating the immune system to respond to these proteins in a less reactive manner.

Cyrex™ Labs, Inc. provides the most comprehensive tests for Delayed Food Allergy Testing. They are a clinical immunology lab specializing in functional immunology and autoimmunity. Cyrex™offers multi-tissue antibody testing for the early detection and monitoring of today’s complex autoimmune conditions, which always include food intolerances. Cyrex™ has provided the most specific information to assist in guiding patient care for the most compromised of gut/auto and hyperimmune cases. You can view all of the tests or “arrays” Cyrex™ Labs offers below or go to: https://www.cyrexlabs.com

Cyrex Labs Arrays:

• Alzheimer’s LINX™ – Alzheimer’s-Associated Immune Reactivity
• Array 2 – Intestinal Antigenic Permeability Screen
• Array 3X – Wheat/Gluten Proteome Reactivity & Autoimmunity
• Array 4 – Gluten-Associated Cross-Reactive Foods and Foods Sensitivity
• Array 5 – Multiple Autoimmune Reactivity Screen
• Array 6 – Diabetes Autoimmune Reactivity Screen
• Array 7 – Neurological Autoimmune Reactivity Screen
• Array 7X – Neurological Autoimmune Reactivity Screen – Expanded
• Array 8 – Joint Autoimmune Reactivity Screen
• Array 10 – Multiple Food Immune Reactivity Screen
• Array 10-90 – Multiple Food Immune Reactivity Screen
• Array 10-90X – Multiple Food Immune Reactivity Screen
• Array 11 – Chemical Immune Reactivity Screen
• Array 12 – Pathogen-Associated Immune Reactivity Screen
• Array 14 – Mucosal Immune Reactivity Screen
• Array 20 – Blood Brain Barrier Permeability
• Array 22 – Irritable Bowel/SIBO Screen
• Total Serum IgG/IgA/IgM
• The Lymphocyte MAP™ – Comprehensive Lymphocyte Immunophenotyping

Spectracell Labs – Micronutrient Testing

SpectraCell’s Micronutrient Testing results allow insight into the nutritional factors that contribute to many clinical conditions including; arthritis, cancer, cardiovascular risk, diabetes, malabsorption of nutrients, and various immunological, metabolic or neurological disorders. The test can provide guidance to what nutrients are most needed for your body’s optimal functioning. Once this test is conducted, it is best to re-test in minimum 3 months and up to 9 months to see if nutritional changes adopted had efficacy.

Clinical Applications:

• Cancer
• Cardiovascular disease
• Diabetes
• Neurological disorders/Alzheimer’s
• Autism and other spectrum disorders
• Mood disorders
• Fatigue
• Osteoporosis
• Fertility issues
• Weight issues
• Sports performance optimization

SpectraCell’s Lipid Protein Profile Plus Testing:

SpectraCell’s Lipid Protien Profile Plus test offers a clinically relevant evaluation to help define risk for atherosclerotic cardiovascular disease (ASCVD), and inflammation. It includes SpectraCell’s Lipoprotein Particle Profile™ Plus (LPPTM Plus), which measures lipoprotein size and density; cardiovascular risk stratification; and also includes triglycerides and traditional cholesterol screening. Results of testing allow clinicians to know when guidance, educational referral, or treatment is necessary.

LPP® Plus Profile

• Lipoprotein Fractionation
• Lipoprotein Particle Numbers
• Total Cholesterol
• Total LDL Particles
• Total HDL Particles
• Triglycerides
• Lipoprotein (a)
• hs-CRP
• Homocysteine
• Apolipoprotein A-1
• Apolipoprotein B
• Insulin

MTHFR

MTHFR is an enzyme responsible for converting 5,10-methylenetetrahydrofolate to the product 5-methyltetrahydrofolate – it is involved in the metabolism of folate and homocysteine. The product of the reaction catalyzed by MTHFR converts homocysteine (a potentially toxic amino acid) to methionine (a useful and necessary amino acid). Many people’s MTHFR is defective meaning they have one or two single nucleotide polymorphism or “SNPs” on it. When that is the case, synthetic folic acid that may be in a nutritional supplement they take may not work well. The natural type of folate is what the body recognizes either through consuming more leafy green vegetables, and in many cases a pharmaceutical grade folate supplement.

MTHFR SNPs can cause hyperhomocysteinemia (especially if folate levels are low); affect nervous system, behavioral, and vascular health; contribute to birth defects, miscarriage, and preeclampsia; modulate cancer risk; and increase chronic disease risk.

Spectracell Labs has an extensive educational library of peer reviewed articles relating to their lab anylates: https://spectracell.sitewrench.com/clinical-education-center

GI Microbial Assay Plus (GI-MAP) is the first comprehensive pathogens assay that is FDA approved. The test manufacturer is Luminex Corp. The pathogen targeted include bacteria, parasites and viruses.

Unlike previous PCR assays, Diagnostic Solutions has fully validated each target organism in their panel resulting in a high confidence in the results. The panel includes opportunistic organisms, normal flora, parasites, and fungi. DNA/PCR techniques also allow for the measurement of antibiotic resistance genes and virulence factors that contribute to pathogenicity. Both are used to help determine clinical significance and the most effective treatments.

We recommend this test for all patients with any type of gastrointestinal challenge, neurological or arthritic health challenges, or anyone who wants to make sure there intestinal microbiome is in a good balance of “good and bad bugs”.

Some conditions that warrant GI-MAP testing are:

• Autoimmune diseases
• IBS/IBD
• Digestive complaints, diarrhea or constipation
• Brain fog
• Skin problems, like acne and psoriasis
• Mood disorders, depression, and anxiety
• Diabetes and weight loss issues

Going to the Diagnostic Solutions Lab Site will educate you further on this test: https://www.diagnosticsolutionslab.com/tests/gi-map

Genova Diagnostic Labs

NutrEval Plasma® test is an advanced nutritional analysis designed to reveal nutritional imbalances or inadequacies in vitamins, Minerals, gastrointestinal, neurological. NutrEval Plasma evaluates the functional need for antioxidants, B-vitamins, minerals, essential fatty acids, amino acids, digestive support, and other select nutrients. The NutrEval test is actually many functional tests rolled into one.

NutrEval Plasma is Part of an Innovative Line of Nutritional Assessments:

• NutrEval® FMV – same comprehensive nutritional analysis as the NutrEval Plasma offering the amino acid assay in urine
  ONE – nutritional test that includes organic acids and amino acids to evaluate the functional need for nutrients
• Metabolic Analysis Profile – assesses organic acids to evaluate functional need for nutrients
• Amino Acid Analysis – features either plasma or urine amino acid to evaluate the functional need for nutrients
• Essential and Metabolic Fatty Acids – a panel of essential and non-essential fatty acids, including Omega-3 and Omega-6 fatty acids

To fully understand this test, please go to the Genova Diagnostic Lab website and learn more: https://www.gdx.net/product/nutreval-nutritional-test-plasma

Learn more about Genova’s tests here.

Assessment of select genomic markers in conjunction with the NutrEval supports broadened clinical insight and enhanced personalization of therapeutics in an array of patient conditions such as depression, anxiety, cardiovascular disease, cardiometabolic syndrome, inflammatory conditions, and chronic pain syndromes.

NutrEval kit requisitions will now include the option for ordering one or more of the following SNPs:

• MTHFR
• COMT
• TNF-α
• APOE

Address Chronic Disease at the Cellular Level

Precision Point Diagnostics revolutionizes oxidant stress testing with this innovative panel of biomarkers. The Advanced Oxidative Stress profile measures total glutathione, reduced glutathione, F2-isoprostane, and 8-OH-2deoxyguanosine from whole blood and urine specimens. Strong medical and scientific evidence points to oxidative stress as an underlying contributing factor to heart disease,1 neurodegenerative conditions,2-5 cancers,6 and toxicity.7,8 Now you have access to these cutting-edge markers to get an inside look at your patient’s oxidative/reductive (ox-redox) balance. With the results of this test, you can develop a targeted treatment protocol to correct rampant oxidative damage and foster a biochemical environment that makes healing possible.

There is a constant biochemical battle going on in the body to maintain oxidative or reductive balance. If your patient has too much oxidative stress, it could be a major underlying factor in their chronic illness. Most well-known for its role in aging, oxidative stress has been implicated in countless chronic diseases, not limited to Alzheimer’s disease, depression, diabetes, and Parkinson’s. When oxidative stress is rampant and antioxidant enzymes are overwhelmed, it means that mitochondria, DNA, proteins, lipid membranes, and cells are sustaining damage. Cells may die or malfunction. Dysfunctional proteins or DNA can trigger pathology. If rampant oxidative stress is not addressed, it is very difficult to halt or reverse the progression of chronic illness; and other treatments may not have their intended effects.

Learn more about Precision Point’s Advanced Oxidative Stress Test here.